Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 60 Researches
8
USERS' SCORE
Good
Based on 9 Reviews
8
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Colon Care BlendBifidobacterium lactis BL818, Lactobacillus acidophilus (SD-5221), Bifidobacterium lactis (SD-5674), Raw Whole Food Probiotic Blend: Bulgarian Yogurt (milk) Concentrate, ^Eastern European Wild Kefir Culture containing Bifidobacterium lactis, Bifidobacterium longum, Lactobacillus acidophilus, Lactobacillus brevis, Lactobacillus bulgaricus, Lactobacillus casei, Lactobacillus fermentum, Lactobacillus helveticus, Lactobacillus kefiranofaciens, Lactobacillus kefirgranum, Lactobacillus rhamnosus, Lactococcus lactis, Lactococcus cremoris, Streptococcus thermophilus, Lactobacillus kefir, Lactobacillus parakefir, Lactobacillus plantarum, Lactococcus lactis biovar diacetylactis, Leuconostoc lactis, Leuconostoc mesenteroides, Leuconostoc cremoris, Leuconostoc dextranicum, Kluyveromyces marxianus, Brettanomyces anomalus, Debaryomyces hansenii, Saccharomyces unisporus, Saccharomyces turicensis, Saccharomyces cerevisiae, Saccharomyces exiguus, Torulaspora delbrueckii
50 Billion CFU¹
+
Colon Transit Support Enzyme BlendAmylase, Protease, Lactase, Glucoamylase, alpha-Galactosidase, Lipase, Pectinase, Peptidase, Bromelain, Phytase, Hemicellulase, beta-Glucanase, Papain, Cellulase, Xylanase, Diastase, Invertase
50 mg
+
Eastern European Raw Fruit & Veggie BlendRed Bell Pepper (Fruit), Green Pea (Seed), Carrot (Root), Plum (Fruit), Cherry (Fruit), Strawberry (Fruit), Raspberry (Fruit)
45 mg
+
Top Medical Research Studies
9.5
We investigated the potential of Lactococcus lactis, a safe bacterial strain, to deliver protective proteins for preventing type 1 diabetes (T1DM) in NOD mice. Our study used two specially engineered strains that expressed a specific protein.
We found that oral administration of these Lactococcus lactis strains helped stop high blood sugar, enhanced glucose tolerance, and reduced inflammation in the pancreas. This occurred by suppressing certain auto-reactive T cells and encouraging healthy immune responses. Our results suggest that this method could effectively help prevent T1DM in these mice.
We found that oral administration of these Lactococcus lactis strains helped stop high blood sugar, enhanced glucose tolerance, and reduced inflammation in the pancreas. This occurred by suppressing certain auto-reactive T cells and encouraging healthy immune responses. Our results suggest that this method could effectively help prevent T1DM in these mice.
Read More
9
We explored the effects of probiotic LC-STH-13 on systemic lupus erythematosus (SLE) in MRL/lpr mice. Our study demonstrated that LC-STH-13 significantly decreased harmful autoantibodies and rebalanced specific immune cells.
We also observed reduced immune cell infiltration in kidney tissue, indicating less inflammation. Furthermore, the probiotic helped restore healthy gut microbiota which gets disrupted by SLE. These findings suggest that LC-STH-13 may offer a novel way to manage lupus by targeting both immune regulation and gut health.
We also observed reduced immune cell infiltration in kidney tissue, indicating less inflammation. Furthermore, the probiotic helped restore healthy gut microbiota which gets disrupted by SLE. These findings suggest that LC-STH-13 may offer a novel way to manage lupus by targeting both immune regulation and gut health.
Read More
9
Lactobacillus acidophilus shows promise in autoimmune management
We explored how specific Lactobacillus acidophilus strains can impact autoimmune disorders by reducing leptin production in mice. In our study, we compared the effects of CBA4P and other lactobacilli on adipocytes from mice sensitive to Th1 immune diseases.
Results showed that CBA4P significantly lowered leptin levels and inhibited the activation of immune lymphocytes in the SJL mouse strain. This suggests that CBA4P might help manage Th1-related inflammatory conditions, representing a potentially valuable probiotic option for autoimmune control.
Results showed that CBA4P significantly lowered leptin levels and inhibited the activation of immune lymphocytes in the SJL mouse strain. This suggests that CBA4P might help manage Th1-related inflammatory conditions, representing a potentially valuable probiotic option for autoimmune control.
Read More
Most Useful Reviews
7.5
Normalised digestion
36 people found this helpful
Super probiotics! I've already ordered them four times. My husband has struggled with bowel issues for years, alongside unpleasant breath that I thought was dental-related but turned out to be gastric. Since starting these pills, his bowel movements became regular, and the bad breath disappeared. He now takes them every other day after initially taking them daily. Although they are rather pricey, they have proven to be worth it.
Read More
9
Constipation relieved
7 people found this helpful
Excellent probiotics! After using them for the first month, my bowel function improved, and constipation disappeared completely. I'm ordering them for the third time now, and I'm very pleased with the results. I strongly recommend them!
Read More
9
Effective gastrointestinal aid
2 people found this helpful
My intestines have troubled me since childhood, so when I found these probiotics with rich ingredients, I quickly ordered them and haven’t regretted it. They’ve effectively improved my gastrointestinal health; the heaviness in my stomach has vanished, heartburn is gone, and my digestion has normalised. I’m very satisfied with this purchase!
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 60 Researches
8
- All Researches
9.5
We investigated the potential of Lactococcus lactis, a safe bacterial strain, to deliver protective proteins for preventing type 1 diabetes (T1DM) in NOD mice. Our study used two specially engineered strains that expressed a specific protein.
We found that oral administration of these Lactococcus lactis strains helped stop high blood sugar, enhanced glucose tolerance, and reduced inflammation in the pancreas. This occurred by suppressing certain auto-reactive T cells and encouraging healthy immune responses. Our results suggest that this method could effectively help prevent T1DM in these mice.
We found that oral administration of these Lactococcus lactis strains helped stop high blood sugar, enhanced glucose tolerance, and reduced inflammation in the pancreas. This occurred by suppressing certain auto-reactive T cells and encouraging healthy immune responses. Our results suggest that this method could effectively help prevent T1DM in these mice.
Read More
9
We examined how a special probiotic mix, known as IRT5, affects autoimmune diabetes in non-obese diabetic (NOD) mice. Administered frequently over 36 weeks, this combination not only reduced diabetes incidence but also lowered insulitis scores and increased insulin-producing β-cell mass.
Additionally, IRT5 improved gut health and changed the makeup of immune cells in the pancreas and intestines. While some immune responses stayed the same, the shift towards more gut-focused regulatory T cells suggests it could be a promising treatment for type 1 diabetes.
Additionally, IRT5 improved gut health and changed the makeup of immune cells in the pancreas and intestines. While some immune responses stayed the same, the shift towards more gut-focused regulatory T cells suggests it could be a promising treatment for type 1 diabetes.
Read More
9
Synbiotics improve rheumatoid arthritis symptoms
We investigated how synbiotic supplementation affects patients with rheumatoid arthritis (RA). In an 8-week, randomized, double-blind trial involving 54 participants, we compared the outcomes of those taking synbiotic capsules with a placebo group.
After the trial, those who received synbiotics showed a significant drop in inflammation markers and pain levels. Additionally, improvements were observed in insulin resistance and overall metabolic responses.
These findings suggest that synbiotics might benefit individuals managing RA by reducing inflammation and enhancing metabolic health.
After the trial, those who received synbiotics showed a significant drop in inflammation markers and pain levels. Additionally, improvements were observed in insulin resistance and overall metabolic responses.
These findings suggest that synbiotics might benefit individuals managing RA by reducing inflammation and enhancing metabolic health.
Read More
9
Lactobacillus acidophilus shows promise in autoimmune management
We explored how specific Lactobacillus acidophilus strains can impact autoimmune disorders by reducing leptin production in mice. In our study, we compared the effects of CBA4P and other lactobacilli on adipocytes from mice sensitive to Th1 immune diseases.
Results showed that CBA4P significantly lowered leptin levels and inhibited the activation of immune lymphocytes in the SJL mouse strain. This suggests that CBA4P might help manage Th1-related inflammatory conditions, representing a potentially valuable probiotic option for autoimmune control.
Results showed that CBA4P significantly lowered leptin levels and inhibited the activation of immune lymphocytes in the SJL mouse strain. This suggests that CBA4P might help manage Th1-related inflammatory conditions, representing a potentially valuable probiotic option for autoimmune control.
Read More
9
We examined how probiotics, specifically Lactobacillus rhamnosus, could help with rheumatoid arthritis (RA) symptoms. By isolating monocytes from RA patients and healthy individuals, we created macrophages and tested various treatments.
Our findings revealed that probiotics encouraged macrophages to adopt a more anti-inflammatory state. They increased beneficial cytokines while lowering inflammatory ones. This suggests a potential role for probiotics in managing RA, showing they might help modulate immune responses and improve symptoms.
Our findings revealed that probiotics encouraged macrophages to adopt a more anti-inflammatory state. They increased beneficial cytokines while lowering inflammatory ones. This suggests a potential role for probiotics in managing RA, showing they might help modulate immune responses and improve symptoms.
Read More
User Reviews
USERS' SCORE
Good
Based on 9 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Normalised digestion
36 people found this helpful
Super probiotics! I've already ordered them four times. My husband has struggled with bowel issues for years, alongside unpleasant breath that I thought was dental-related but turned out to be gastric. Since starting these pills, his bowel movements became regular, and the bad breath disappeared. He now takes them every other day after initially taking them daily. Although they are rather pricey, they have proven to be worth it.
Read More
9
Constipation relieved
7 people found this helpful
Excellent probiotics! After using them for the first month, my bowel function improved, and constipation disappeared completely. I'm ordering them for the third time now, and I'm very pleased with the results. I strongly recommend them!
Read More
9
Effective gastrointestinal aid
2 people found this helpful
My intestines have troubled me since childhood, so when I found these probiotics with rich ingredients, I quickly ordered them and haven’t regretted it. They’ve effectively improved my gastrointestinal health; the heaviness in my stomach has vanished, heartburn is gone, and my digestion has normalised. I’m very satisfied with this purchase!
Read More
7.5
Effective absorption
32 people found this helpful
Every penny spent is justified. The packaging includes cooling seals, which helps maintain bacterial safety during transport. My husband and I have been taking one capsule daily for three weeks. I’ve noticed the white coating on my tongue has disappeared, and my digestion is functioning perfectly. My husband’s irritable bowel symptoms have improved as well. I believe that these probiotics enhance the absorption of other vitamins I’m taking. I’ve ordered multiple jars. Highly recommend!
Read More
9
Gut health improved
3 people found this helpful
This product features high-quality probiotics combined with digestive enzymes, which have greatly benefited my girlfriend, who previously suffered from constipation for days. After taking them for two months, she now has regular bowel movements. A true lifesaver!
Read More
Frequently Asked Questions
7.5
Effective absorption
32 people found this helpful
Every penny spent is justified. The packaging includes cooling seals, which helps maintain bacterial safety during transport. My husband and I have been taking one capsule daily for three weeks. I’ve noticed the white coating on my tongue has disappeared, and my digestion is functioning perfectly. My husband’s irritable bowel symptoms have improved as well. I believe that these probiotics enhance the absorption of other vitamins I’m taking. I’ve ordered multiple jars. Highly recommend!
9
Constipation relieved
7 people found this helpful
Excellent probiotics! After using them for the first month, my bowel function improved, and constipation disappeared completely. I'm ordering them for the third time now, and I'm very pleased with the results. I strongly recommend them!
7.5
Need consistent use
3 people found this helpful
Excellent! I believe it works, but extended use, likely six months or longer, is necessary for lasting effects. During my time taking these capsules, I noticed a boost in my digestive activity, with regular bowel movements. I plan to order more. Each capsule contains an impressive 50 billion bacteria, allowing for convenient once-daily use.
0
No results achieved
I took a capsule daily for a month but noticed no difference. My digestive issues remained unresolved. For the price, the results were non-existent. I won't be ordering again!
7.5
Normalised digestion
36 people found this helpful
Super probiotics! I've already ordered them four times. My husband has struggled with bowel issues for years, alongside unpleasant breath that I thought was dental-related but turned out to be gastric. Since starting these pills, his bowel movements became regular, and the bad breath disappeared. He now takes them every other day after initially taking them daily. Although they are rather pricey, they have proven to be worth it.
9
Effective gastrointestinal aid
2 people found this helpful
My intestines have troubled me since childhood, so when I found these probiotics with rich ingredients, I quickly ordered them and haven’t regretted it. They’ve effectively improved my gastrointestinal health; the heaviness in my stomach has vanished, heartburn is gone, and my digestion has normalised. I’m very satisfied with this purchase!
9
Gut health improved
3 people found this helpful
This product features high-quality probiotics combined with digestive enzymes, which have greatly benefited my girlfriend, who previously suffered from constipation for days. After taking them for two months, she now has regular bowel movements. A true lifesaver!
7.5
Improved digestion
1 people found this helpful
On my doctor's advice, I purchased this product to support my gut flora. Containing 33 probiotics and 17 enzymes, it provides all the necessary support in one capsule! I've felt improved digestion and comfort in my stomach during my use. Taken at night on an empty stomach, it caused no unwanted effects. I took two packs over a month and felt only positive results.
8
We explored the effects of Lactobacillus acidophilus and propionate on Sjögren's syndrome in a mouse model. Our study involved comparing the gut microbiomes of young and older mice while treating them for up to 24 weeks.
Notably, we observed that Lactobacillus acidophilus improved symptoms of Sjögren's syndrome and led to an increase in beneficial propionate-producing bacteria. This treatment appears to work by modulating key signaling pathways involved in the condition.
Overall, our findings suggest that Lactobacillus acidophilus and propionate might offer promising therapeutic options for managing Sjögren's syndrome.
Notably, we observed that Lactobacillus acidophilus improved symptoms of Sjögren's syndrome and led to an increase in beneficial propionate-producing bacteria. This treatment appears to work by modulating key signaling pathways involved in the condition.
Overall, our findings suggest that Lactobacillus acidophilus and propionate might offer promising therapeutic options for managing Sjögren's syndrome.
7
Probiotics improve inflammation in RA
We examined how a mix of probiotics, including Lactobacillus acidophilus, affects inflammation in people with rheumatoid arthritis (RA). In a double-blind study with 42 participants, we found that those taking probiotics had lower white blood cell counts and reduced levels of specific inflammatory markers.
While our results showed improvements in oxidative stress profiles, such as higher antioxidant levels, some inflammatory markers remained unchanged. Overall, probiotic supplementation appears to offer benefits for managing RA through reduced inflammation and improved oxidative status.
While our results showed improvements in oxidative stress profiles, such as higher antioxidant levels, some inflammatory markers remained unchanged. Overall, probiotic supplementation appears to offer benefits for managing RA through reduced inflammation and improved oxidative status.
8
This randomized, double-blind trial sought to see how synbiotics, including Lactobacillus acidophilus, could help patients with systemic lupus erythematosus (SLE). Fifty patients were divided into two groups: one received synbiotics alongside their standard therapy, while the other got standard therapy alone over two months.
We observed that those who took the synbiotics showed a meaningful drop in inflammatory markers like interleukin-17A and overall disease activity. Meanwhile, the placebo group didn’t see these improvements. While these findings are promising, we recognize that more research is necessary to fully understand how synbiotics work in SLE management.
We observed that those who took the synbiotics showed a meaningful drop in inflammatory markers like interleukin-17A and overall disease activity. Meanwhile, the placebo group didn’t see these improvements. While these findings are promising, we recognize that more research is necessary to fully understand how synbiotics work in SLE management.
8
Lactic acid bacteria combat autoimmune symptoms
We investigated the potential of Lactobacillus and Bifidobacterium in alleviating symptoms of multiple sclerosis using a rat model. The study involved 48 male rats, which were divided into groups to evaluate the effects of these bacteria on demyelination caused by cuprizone.
The results showed that treatment with lactic acid bacteria notably improved behavioral impairments, decreased demyelination, reduced oxidative stress, and elevated serum levels of vitamins D and B.
Overall, these findings indicate that Lactobacillus and Bifidobacterium may be beneficial in managing autoimmune conditions like multiple sclerosis.
The results showed that treatment with lactic acid bacteria notably improved behavioral impairments, decreased demyelination, reduced oxidative stress, and elevated serum levels of vitamins D and B.
Overall, these findings indicate that Lactobacillus and Bifidobacterium may be beneficial in managing autoimmune conditions like multiple sclerosis.
References
- Kazemimiraki M, Moazamian E, Mokhtari MJ, Gholamzad M. The Role of Lactic Acid Bacteria in Improving Behavioral Deficits, Serum Levels of Vitamin D3, B12 and Reducing Oxidative Stress and Demyelination in a Cuprizone-induced Demyelination Model of Rat. Neuromolecular Med. 2025;27:14. doi:10.1007/s12017-025-08837-1
- Mirfeizi Z, Mahmoudi M, Jokar MH, Sahebari M, Noori E, et al. Impact of synbiotics on disease activity in systemic lupus erythematosus: Results from a randomized clinical trial. J Food Sci. 2024;89:9835. doi:10.1111/1750-3841.17460
- Woo JS, Hwang SH, Yang S, Lee KH, Lee YS, et al. Lactobacillus acidophilus and propionate attenuate Sjögren's syndrome by modulating the STIM1-STING signaling pathway. Cell Commun Signal. 2023;21:135. doi:10.1186/s12964-023-01141-0
- Kim DS, Park Y, Choi JW, Park SH, Cho ML, et al. Supplementation Exerts a Synergistic Effect on Tacrolimus Efficacy by Modulating Th17/Treg Balance in Lupus-Prone Mice the SIGNR3 Pathway. Front Immunol. 2021;12:696074. doi:10.3389/fimmu.2021.696074
- Cannarella LAT, Mari NL, Alcântara CC, Iryioda TMV, Costa NT, et al. Mixture of probiotics reduces inflammatory biomarkers and improves the oxidative/nitrosative profile in people with rheumatoid arthritis. Nutrition. 2021;89:111282. doi:10.1016/j.nut.2021.111282
- Kim TK, Lee JC, Im SH, Lee MS. Amelioration of Autoimmune Diabetes of NOD Mice by Immunomodulating Probiotics. Front Immunol. 2020;11:1832. doi:10.3389/fimmu.2020.01832
- Kamal Y, Kandil M, Eissa M, Yousef R, Elsaadany B. Probiotics as a prophylaxis to prevent oral candidiasis in patients with Sjogren's syndrome: a double-blinded, placebo-controlled, randomized trial. Rheumatol Int. 2020;40:873. doi:10.1007/s00296-020-04558-9
- Kim J, Choi SH, Kim YJ, Jeong HJ, Ryu JS, et al. Clinical Effect of IRT-5 Probiotics on Immune Modulation of Autoimmunity or Alloimmunity in the Eye. Nutrients. 2017;9. doi:10.3390/nu9111166
- Tamtaji OR, Kouchaki E, Salami M, Aghadavod E, Akbari E, et al. The Effects of Probiotic Supplementation on Gene Expression Related to Inflammation, Insulin, and Lipids in Patients With Multiple Sclerosis: A Randomized, Double-Blind, Placebo-Controlled Trial. J Am Coll Nutr. 2017;36:660. doi:10.1080/07315724.2017.1347074
- Zamani B, Farshbaf S, Golkar HR, Bahmani F, Asemi Z. Synbiotic supplementation and the effects on clinical and metabolic responses in patients with rheumatoid arthritis: a randomised, double-blind, placebo-controlled trial. Br J Nutr. 2017;117:1095. doi:10.1017/S000711451700085X
- Zamani B, Golkar HR, Farshbaf S, Emadi-Baygi M, Tajabadi-Ebrahimi M, et al. Clinical and metabolic response to probiotic supplementation in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled trial. Int J Rheum Dis. 2016;19:869. doi:10.1111/1756-185X.12888
- Bleau C, Lamontagne L, Savard R. New Lactobacillus acidophilus isolates reduce the release of leptin by murine adipocytes leading to lower interferon-gamma production. Clin Exp Immunol. 2005;140:427.
- Ahmadi P, Mahmoudi M, Rafatpanah H, Rezaieyazdi Z, Ahmadi-Khorram M, et al. The Impacts of and to Promote In Vitro Anti-Inflammatory Profile of RA-Macrophages. Food Sci Nutr. 2025;13:e70068. doi:10.1002/fsn3.70068
- Liao W, Zhang X, Jia C, Chen W, Cai Y, et al. LC-STH-13 ameliorates the progression of SLE in MRL/lpr mice by inhibiting the TLR9/NF-κB signaling pathway. Food Funct. 2025;16:475. doi:10.1039/d4fo03966a
- Javanmardi Z, Mahmoudi M, Rafatpanah H, Rezaieyazdi Z, Shapouri-Moghaddam A, et al. Tolerogenic probiotics Lactobacillus delbrueckii and Lactobacillus rhamnosus promote anti-inflammatory profile of macrophages-derived monocytes of newly diagnosed patients with systemic lupus erythematosus. Cell Biochem Funct. 2024;42:e3981. doi:10.1002/cbf.3981
- Vahidi Z, Saghi E, Mahmoudi M, RezaieYazdi Z, Esmaeili SA, et al. Lactobacillus rhamnosus and Lactobacillus delbrueckii Ameliorate the Expression of miR-125a and miR-146a in Systemic Lupus Erythematosus Patients. Appl Biochem Biotechnol. 2024;196:6330. doi:10.1007/s12010-023-04827-w
- Hoseinzadeh A, Mahmoudi M, Rafatpanah H, Rezaieyazdi Z, Tavakol Afshari J, et al. A new generation of mesenchymal stromal/stem cells differentially trained by immunoregulatory probiotics in a lupus microenvironment. Stem Cell Res Ther. 2023;14:358. doi:10.1186/s13287-023-03578-z
- Tripathy A, Swain N, Padhan P, Raghav SK, Gupta B. Lactobacillus rhamnosus reduces CD8T cell mediated inflammation in patients with rheumatoid arthritis. Immunobiology. 2023;228:152415. doi:10.1016/j.imbio.2023.152415
- Furone F, Bellomo C, Carpinelli M, Nicoletti M, Hewa-Munasinghege FN, et al. The protective role of GG postbiotic on the alteration of autophagy and inflammation pathways induced by gliadin in intestinal models. Front Med (Lausanne). 2023;10:1085578. doi:10.3389/fmed.2023.1085578
- Lin H, Lin J, Pan T, Li T, Jiang H, et al. Polymeric immunoglobulin receptor deficiency exacerbates autoimmune hepatitis by inducing intestinal dysbiosis and barrier dysfunction. Cell Death Dis. 2023;14:68. doi:10.1038/s41419-023-05589-3
- Samani SA, Moloudi MR, Ramezanzadeh R, Abdi M, Nikkhoo B, et al. Oral Administration of Probiotic to Ameliorate Experimental Autoimmune Encephalomyelitis in Mice. Basic Clin Neurosci. 2022;13:35. doi:10.32598/bcn.2021.1955.1
- Monzani R, Gagliardi M, Clemente N, Saverio V, Pańczyszyn E, et al. The Gut-Ex-Vivo System (GEVS) Is a Dynamic and Versatile Tool for the Study of DNBS-Induced IBD in BALB/C and C57BL/6 Mice, Highlighting the Protective Role of Probiotics. Biology (Basel). 2022;11. doi:10.3390/biology11111574
- Petersen AØ, Jokinen M, Plichta DR, Liebisch G, Gronwald W, et al. Cytokine-specific autoantibodies shape the gut microbiome in autoimmune polyendocrine syndrome type 1. J Allergy Clin Immunol. 2021;148:876. doi:10.1016/j.jaci.2021.03.025
- Liu Y, Hoang TK, Taylor CM, Park ES, Freeborn J, et al. and differentially affect gut microbes and metabolites in mice with Treg deficiency. Am J Physiol Gastrointest Liver Physiol. 2021;320:G969. doi:10.1152/ajpgi.00072.2021
- Fan Z, Yang B, Ross RP, Stanton C, Zhao J, et al. The prophylactic effects of different Lactobacilli on collagen-induced arthritis in rats. Food Funct. 2020;11:3681. doi:10.1039/c9fo02556a
- Khorasani S, Mahmoudi M, Kalantari MR, Lavi Arab F, Esmaeili SA, et al. Amelioration of regulatory T cells by Lactobacillus delbrueckii and Lactobacillus rhamnosus in pristane-induced lupus mice model. J Cell Physiol. 2019;234:9778. doi:10.1002/jcp.27663
- Mardani F, Mahmoudi M, Esmaeili SA, Khorasani S, Tabasi N, et al. In vivo study: Th1-Th17 reduction in pristane-induced systemic lupus erythematosus mice after treatment with tolerogenic Lactobacillus probiotics. J Cell Physiol. 2018;234:642. doi:10.1002/jcp.26819
- Piva F, Gervois P, Karrout Y, Sané F, Romond MB. Gut-Joint Axis: Impact of Bifidobacterial Cell Wall Lipoproteins on Arthritis Development. Nutrients. 2023;15. doi:10.3390/nu15234861
- Huo D, Cen C, Chang H, Ou Q, Jiang S, et al. Probiotic Bifidobacterium longum supplied with methimazole improved the thyroid function of Graves' disease patients through the gut-thyroid axis. Commun Biol. 2021;4:1046. doi:10.1038/s42003-021-02587-z
- Li D, Cheng J, Zhu Z, Catalfamo M, Goerlitz D, et al. Treg-inducing capacity of genomic DNA of subsp. . Allergy Asthma Proc. 2020;41:372. doi:10.2500/aap.2020.41.200064
- Shi P, Qu H, Nian D, Chen Y, Liu X, et al. Treatment of Guillain-Barré syndrome with Bifidobacterium infantis through regulation of T helper cells subsets. Int Immunopharmacol. 2018;61:290. doi:10.1016/j.intimp.2018.06.015
- Laparra JM, Olivares M, Sanz Y. Oral administration of Bifidobacterium longum CECT 7347 ameliorates gliadin-induced alterations in liver iron mobilisation. Br J Nutr. 2013;110:1828. doi:10.1017/S0007114513001098
- Laparra JM, Olivares M, Gallina O, Sanz Y. Bifidobacterium longum CECT 7347 modulates immune responses in a gliadin-induced enteropathy animal model. PLoS One. 2012;7:e30744. doi:10.1371/journal.pone.0030744
- Yang Y, Hong Q, Zhang X, Liu Z. BD400 protects from collagen-induced arthritis through histidine metabolism. Front Immunol. 2025;16:1518181. doi:10.3389/fimmu.2025.1518181
- Wang CH, Yen HR, Lu WL, Ho HH, Lin WY, et al. Adjuvant Probiotics of subsp. AP-32, MH-68, and subsp. CP-9 Attenuate Glycemic Levels and Inflammatory Cytokines in Patients With Type 1 Diabetes Mellitus. Front Endocrinol (Lausanne). 2022;13:754401. doi:10.3389/fendo.2022.754401
- Zhang H, Liu M, Liu X, Zhong W, Li Y, et al. ssp. Lactis 420 Mitigates Autoimmune Hepatitis Through Regulating Intestinal Barrier and Liver Immune Cells. Front Immunol. 2020;11:569104. doi:10.3389/fimmu.2020.569104
- Cardoso RS, Messora MR, Silva PHF, Oliveira LF, Leite-Panissi C, et al. Effects of subsp. HN019 on ligature-induced periodontitis in rats with experimental rheumatoid arthritis. Benef Microbes. 2020;11:33. doi:10.3920/BM2019.0038
- Salehipour Z, Haghmorad D, Sankian M, Rastin M, Nosratabadi R, et al. Bifidobacterium animalis in combination with human origin of Lactobacillus plantarum ameliorate neuroinflammation in experimental model of multiple sclerosis by altering CD4+ T cell subset balance. Biomed Pharmacother. 2017;95:1535. doi:10.1016/j.biopha.2017.08.117
- Ezendam J, de Klerk A, Gremmer ER, van Loveren H. Effects of Bifidobacterium animalis administered during lactation on allergic and autoimmune responses in rodents. Clin Exp Immunol. 2008;154:424. doi:10.1111/j.1365-2249.2008.03788.x
- Tian C, Yan M, Guo J, Zhou Y, Du B, et al. Yeast Cell Wall-Mediated Ileal Targeted Delivery System for IgA Nepharopathy Therapy. ACS Biomater Sci Eng. 2025;11:1498. doi:10.1021/acsbiomaterials.4c01941
- Vuscan P, Röring RJ, Kischkel B, Tintoré M, Cuñé J, et al. Effect of Saccharomyces cerevisiae β-glucan on the T helper cytokine profile. Cytokine. 2025;187:156871. doi:10.1016/j.cyto.2025.156871
- Lee C, Verma R, Byun S, Jeun EJ, Kim GC, et al. Structural specificities of cell surface β-glucan polysaccharides determine commensal yeast mediated immuno-modulatory activities. Nat Commun. 2021;12:3611. doi:10.1038/s41467-021-23929-9
- de Campos Fraga-Silva TF, Mimura LAN, de Oliveira LRC, Dos Santos Toledo JH, Borim PA, et al. Selenization of S. cerevisiae increases its protective potential in experimental autoimmune encephalomyelitis by triggering an intestinal immunomodulatory loop. Sci Rep. 2020;10:22190. doi:10.1038/s41598-020-79102-7
- Alvarez P, Augustín JJ, Tamayo E, Iglesias M, Acinas O, et al. Therapeutic Effects of Anti-Bone Morphogenetic Protein and Activin Membrane-Bound Inhibitor Treatment in Psoriasis and Arthritis. Arthritis Rheumatol. 2020;72:1547. doi:10.1002/art.41272
- Aboud C, Zamaria N, Cannistrà C. Treatment of hidradenitis suppurativa: Surgery and yeast (Saccharomyces cerevisiae)-exclusion diet. Results after 6 years. Surgery. 2020;167:1012. doi:10.1016/j.surg.2019.12.015
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